Force-frequency relation in human heart failure.
نویسندگان
چکیده
منابع مشابه
Altered myocardial force-frequency relation in human heart failure.
BACKGROUND In congestive heart failure (idiopathic dilated cardiomyopathy), exercise is accompanied by a smaller-than-normal decrease in end-diastolic left ventricular volume, depressed peak rates of left ventricular pressure rise and fall, and depressed heart-rate-dependent potentiation of contractility (bowditch treppe). We studied contractile function of isolated left ventricular myocardium ...
متن کاملLevosimendan restores the positive force-frequency relation in heart failure.
Frequency potentiation of contractile function is a major mechanism of the increase in myocardial performance during exercise. In heart failure (HF), this positive force-frequency relation is impaired, and the abnormal left ventricular (LV)-arterial coupling is exacerbated by tachycardia. A myofilament Ca(2+) sensitizer, levosimendan, has been shown to improve exercise tolerance in HF. This may...
متن کاملThe force-frequency relationship in human heart failure: effect of pyruvate and isoproterenol.
PURPOSE The purpose of present study was to investigate the effect of metabolic substrate pyruvate and beta-adrenergic agonist isoproterenol and combination of these agents on the force- and relaxation-frequency relationship in human heart failure. MATERIAL AND METHODS The experiments were performed on isolated human ventricle strips from patients undergoing cardiac corrective open heart surg...
متن کاملForce-Frequency Relationship in the Failing Human Heart
a reduced force of contraction in vivo and in vitro. The present study was aimed to investigate whether inotropic stimulation influences the inverse force-frequency relationship in failing human myocardium. Methods and Results. The effects of the cAMP-independent positive inotropic agents ouabain (0.01 ,imol/L) and BDF 9148 (0.1 ,umol/L) as well as the 3-adrenoceptor agonist isoprenaline (0.01 ...
متن کاملBiventricular pacing improves the blunted force-frequency relation present during univentricular pacing in patients with heart failure and conduction delay.
BACKGROUND In patients with chronic heart failure (CHF) and conduction delay, biventricular (BiV) and left ventricular (LV) pacing similarly improve systolic function at resting heart rates. We hypothesized that BiV and univentricular pacing differentially affect contractile function at increasing heart rates. METHODS AND RESULTS Twenty-two patients (aged 66+/-2 years, QRS 179+/-8 ms, LV ejec...
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ژورنال
عنوان ژورنال: Circulation
سال: 1992
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circ.86.6.1451277